The health of children born prematurely remains a significant challenge, but clothing products designed considering medical requirements and handling methods used in the intensive care unit, may contribute to the reduction of neonatal mortality. Assistants in the therapy unit implement practices based on the needs of vulnerable infants, from the very first second of life. This pilot clinical study was conducted in a specialised on neonatal intensive care unit, at the IMSP Municipal Clinical Hospital Gheorghe Paladi from Chisinau. Informed consent of parents and/or careers was required. All users (nurses and doctors) were informed about the product and instructed regarding dressing and undressing process. This controlled study was conducted under the supervision of doctors and nurses. As the study was exploratory in nature, aspects of grounded theory have been used for qualitative data collection. The sample studied consists of preterm infants less than 30 weeks GA, admitted by UTIN in 2018. The population eligible for qualitative data collection was made up of neonatology nurses from the clinic. To obtain a heterogeneous sample, aspects such as age, work experience, environment, and education were considered. The method of observation and subsequent testing used of the newly designed products and every manipulation under medical conditions was intensely studied. Local reactions, if any, due to the texture and quality of the textile material that come into contact with the baby's skin, were also carefully monitored. The process of dressing and stripping off the products, carrying out medical manipulations (in case of neonatal emergencies), were also carefully observed for developing ease of use clothes.