Alongside many studies on adoption efforts for antifragility practices in business, there is a research gap related to using Stoic principles. This study identifies five approaches derived from Stoic philosophy and examines them in the context of business antifragility. The dichotomy of control, the discipline of thought, responsibility for the future, calm in the face of chaos, and fear as a tool for growth are analyzed based on previous research and examples of entrepreneurial practice. The antifragility concept gained growing attention in research and practice with the pandemic, the economic situation related to the Ukrainian conflict, and the growing influence of digital technologies such as artificial intelligence, blockchain, cloud computing, and big data analytics. However, the literature lacks studies on Stoic approaches to antifragility. We extend knowledge of the emerging antifragility field by mixing it with the ideas of the Stoic philosophy.