Prediction of worsening of skin fibrosis in patients with diffuse cutaneous systemic sclerosis using the EUSTAR database

Maurer Britta; Graf Nicole; Michel Beat A.; Agachi Svetlana; Groppa Liliana; Chiaburu Lealea; Noi Autori

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MAURER, Britta, GRAF, Nicole, MICHEL, Beat A., AGACHI, Svetlana, GROPPA, Liliana, CHIABURU, Lealea, NOI, Autori. Prediction of worsening of skin fibrosis in patients with diffuse cutaneous systemic sclerosis using the EUSTAR database. In: Annals of the Rheumatic Diseases, 2015, vol. 74, pp. 1124-1131. ISSN -. DOI: https://doi.org/10.1136/annrheumdis-2014-205226

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Annals of the Rheumatic Diseases

Volumul 74 / 2015 / ISSN - /ISSNe 0003-4967

Prediction of worsening of skin fibrosis in patients with diffuse cutaneous systemic sclerosis using the EUSTAR database

DOI:https://doi.org/10.1136/annrheumdis-2014-205226

Pag. 1124-1131

Maurer Britta¹, Graf Nicole², Michel Beat A.¹, Agachi Svetlana³, Groppa Liliana³, Chiaburu Lealea³, Noi Autori

¹ University Hospital Zurich,
² Graf Biostatistics, Winterthur,
³ St. Trinity Municipal Clinical Hospital

Disponibil în IBN: 23 iunie 2023

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Objectives To identify predictive parameters for the progression of skin fibrosis within 1 year in patients with diffuse cutaneous SSc (dcSSc). Methods An observational study using the EUSTAR database was performed. Inclusion criteria were dcSSc, American College of Rheumatology (ACR) criteria fulfilled, modified Rodnan skin score (MRSS) ≥7 at baseline visit, valid data for MRSS at 2nd visit, and available follow-up of 12±2 months. Worsening of skin fibrosis was defined as increase in MRSS >5 points and ≥25% from baseline to 2nd visit. In the univariate analysis, patients with progressive fibrosis were compared with non-progressors, and predictive markers with p[removed]

Cuvinte-cheie
MeSH Adult, Cohort Studies, Creatine Kinase, databases, Factual, Decision Support Techniques, Deglutition Disorders, disease progression, dyspnea, female, fibrosis, Humans, Logistic Models, Male, middle aged, Multivariate Analysis, Scleroderma, diffuse, Severity of Illness Index, Sex Factors, skin, Synovitis, Time Factors EMTREE drug terms immunosuppressive agent, creatine kinase EMTREE medical terms adult, article, clinical feature, cohort analysis, controlled study, data analysis, diffuse cutaneous systemic sclerosis, diffuse cutaneous systemic sclerosis, disease association, disease duration, drug effect, drug response, female, follow up, general condition deterioration, human, major clinical study, Male, middle aged, observational study, prediction, priority journal, scoring system, skin fibrosis, syndrome delineation, Synovitis, systemic sclerosis, blood, complication, decision support system, Deglutition Disorders, diffuse scleroderma, disease course, dyspnea, factual database, fibrosis, Multivariate Analysis, pathology, Severity of Illness Index, sex difference, skin, statistical model, Synovitis, time