Conţinutul numărului revistei |
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Articolul urmator |
255 0 |
SM ISO690:2012 FULGA, Veaceslav, RUDICO, Lucian, BALICA, Amalia Raluca, CIMPEAN, Anca-Maria, ŞAPTEFRAŢI, Lilian, MARGAN, Madalin-Marius, RAICA, Marius. Differential expression of E-cadherin in primary breast cancer and corresponding lymph node metastases. In: Anticancer Research, 2015, vol. 35, nr. 2, pp. 759-765. ISSN 0250-7005. |
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Anticancer Research | |
Volumul 35, Numărul 2 / 2015 / ISSN 0250-7005 /ISSNe 1791-7530 | |
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Pag. 759-765 | |
Rezumat | |
Background/Aim: E-Cadherin is a marker with a controversial function. Its role is often interpreted in the context of the epithelial-mesenchymal transition. In ambiguous cases, it is used as a phenotypic marker of lobular subtype of breast carcinoma. It has been wellstudied in primary cancer, but its expression after metastasis is not well-described. The aim of this study was to determine the evolution of E-cadherin expression in no special type (NST) primary breast carcinoma and to correlate this with that in distant, paired nodal metastases (LNM) and molecular classification. Material and Methods: We processed 88 invasive breast carcinomas of NST type and their paired LNM. The specimens were formalin-fixed and paraffin embedded. Sections were immunostained for estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (Her2), basal cytokeratin CK5, nuclear protein Ki67 and E-cadherin with a Leica Bond-Max autostainer. Results: The results obtained were grouped into four molecular subtypes: Luminal A, luminal B, HER2-overexpressing, and triple-negative/basallike. We found that the frequency of E-cadherin expression was higher (95.45%) in primary sites than in LNM (72.73%). E-Cadherin from primary breast cancer correlated positively only with E-cadherin in LNM (p≤0.003). A single positive correlation of E-cadherin with ER (p≤0.007) LNM was found. Conclusion: E-Cadherin expression is not stable during the metastatic process. Its expression in LNM is lower than in primary sites. ECadherin expression in primary sites positively correlates with E-cadherin from LNM. |
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Cuvinte-cheie breast cancer, Invasive carcinoma NST type, metastasis, molecular subtypes |
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