| Conţinutul numărului revistei |
| Articolul precedent |
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 SM ISO690:2012SIMONOV, Yurii A., FONARI, Marina, DUKA, Gh., GONTA, Maria, GANIN, Edward, YAVOLOVSKII, Arkadii, GDANIEC, Maria, LIPKOWSKI, Janusz. Nitrosation of hydrochlorothiazide and the modes of binding of the N-nitroso derivative with two macrocycles possessing an 18-membered crown ether cavity. In: Tetrahedron, 2005, vol. 61, nr. 27, pp. 6596-6601. ISSN 0040-4020. DOI: https://doi.org/10.1016/j.tet.2005.04.050 |
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  Tetrahedron |
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| Volumul 61, Numărul 27 / 2005 / ISSN 0040-4020 /ISSNe 1464-5416 | |
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| DOI:https://doi.org/10.1016/j.tet.2005.04.050 | |
| Pag. 6596-6601 | |
| Rezumat | |
The hydrochlorothiazide, 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7- sulfonamide-1,1-dioxide, (HCTZ), widely used as a diuretic and anti-hypertensive drug, was transformed into its N-nitroso-derivative, 6-chloro-4-nitroso-3,4- dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide-1,1-dioxide (ON-HCTZ) by sodium nitrite in an acidic medium. The crystalline complexes of ON-HCTZ with 18-crown-6 (18C6) and cis-anti-cis-dicyclohexyl-18C6 (DCH6B) demonstrated different H-bonding modes from those present in the co-crystals of HCTZ with the same crown ethers. The influence of the nitroso-group on the binding mode and crystal packing is discussed. |
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| Cuvinte-cheie Crown ethers, H-binding, N-nitrosohydrochlorothiazide |
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