Introduction: COVID-19 pandemic has a serious impact on emotional and social aspects of individuals. People with mental disorders have a worse prognosis compared to the general population as they have higher risk to develop severe forms of infection and higher mortality rates. Mental disorders might be a risk factor for severe COVID-19. Materials and methods: We performed a descriptive and retrospective analytic study based on medical records from the Clinical Psychiatric Hospital, Republic of Moldova, Chishinau to assess the specific risks of COVID-19-related mortality, hospitalization, and intensive care unit (ICU) admission associated with any pre-existing mental disorder. In the study were included 10587 with mental disorder patients hospitalized between 03.2020 - 03.2022. Results: Of the total number of patients - 572(5,4%) were hospitalized due to COVID-19 infection. Patients with Schizofrenia Spectrum Disorder (SSD) - 66.25% (379), Neurocognitive Disorder(NCD) -14.33%(82) and Major Depresive Disorder (MDD)- 5,45%(26). The total number of patients admitted to ICU due to exacerbation of pre-existing comorbidities were 38.46% (220). The general mortality in mental health unit were 1.19% (126), mortality due to COVID-19 complications 48.41% (61). Of the total mortality number: SSD constituted 31.14% (19), NCD 29.5% (18) and MDD -3.27% (2). Conclusion: Our findings revealed that pre-existing mental disorders increased the risk of COVID-19 mortality. Furthermore, higher mortality was noticed among schizophrenia spectrum disorder and neurocognitive disorders patients compared to mood disorders patients. For psychoticdisorders, mood and neurocognitive disorders the tendency remain regardless of age, sex, and other confounders.