Talk about the Fourth Industrial Revolution is mainly related to the processes of digitalization and the penetration of artificial intelligence into our lives. Business, of course, is also undergoing significant changes under the influence of such cardinal processes. In this context, the social aspects of change are very important, so the management of organizational change should be focused on such extremely important elements as: ethics, social responsibility, values and principles of companies of the future. Without such an important understanding of the transformational processes in society, social inequality can form, the concentration of power and monopolization by only a few large companies, aggravation of problems associated with the failure to implement the goals of the Sustainable Development Concept. The ideologists of the concept of the 4th industrial revolution pay great attention to "soft factors, which, along with technical aspects, lead to a completely different model of the functioning of society. The object of study in the work are the SMEs of the Republic of Moldova, which are the most vulnerable in these challenges. Having insufficient resources and staff qualifications, it is more difficult for them to adapt to such changes, therefore, the purpose of the study is to develop guidelines for the development of enterprises of this type in a complex, uncertain environment of existence.