The negative trends in mortality rates in Transnistria have been noticeably intensified in recent years due to the COVID-19 pandemic. According to regional data, the first death from coronavirus was recorded on March 31, 2020, and so far the total number of deaths from this cause has been 2234 people. An overview of mortality rates is presented, according to the data of the statistical service of Transnistria. In 2021, there was a significant increase in the total number of deaths, as well as an increase in the absolute number of deaths in older age groups. The structure of causes of death has undergone a significant change, among which infectious and parasitic diseases have taken second place, causing almost 20% of deaths in 2021 (compared to 1.4; in 2019). The increase in morbidity and mortality of the population significantly worsens the economic situation in the region.