This paper analyzes the parameters of the biological age of the population of different cities of Russia and Pridnestrovie (Moscow, Barnaul, and Tiraspol). A total of 437 individuals aged 50–90 years (214 men and 223 women) were examined and divided into groups with delayed, moderate, and accelerated aging rates. Regional peculiarities in the distribution of the incidence of different variants of aging rates have been revealed. In Moscovite men and women, the delayed variant of development of age involution changes is the most widespread. In Tiraspol women, as compared to the Moscow group, the incidence of people with accelerated aging rates is two times higher, which can be stipulated by the influence of a complex of biosocial factors.