The research contains evaluation of hydromorphological changes of the rivers from North Development Region of the Republic of Moldova. Main pressures that were analyzed are dykes, channels, reservoirs, settlements, river training. GIS techniques were utilized in order to calculate human impact on hydromorphological state of the rivers. The results show that main pressure that influence on all rivers is reservoir construction on streams. Most affected are rivers from Camenca river basin (Prut basin) as well as Draghiste, Racovat, Solonet and Răuțel. Also, as a high pressure settlements were considered as many of the are situated in river floodplains, and on average 30% of the rivers length passes through them. Less significant are the pressures caused by dykes and irrigation channels, Răut, Răuțel and Camenca (Prut basin) rivers are subject to these influences. Evaluation of river training is less possible due to lack of maps that can show natural rivers shape. However, even so, it can be confirmed that Camenca (Prut basin), Răut, Cubolta and Căinari were the most affected by this activity.