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SM ISO690:2012 DUMINIK, Elena, KRIVCHANSKAYA, Larisa F.. Biochemical predictors of neurological consequences in newborns with hypoxic-ischemic encephalopathy. In: Revista de Ştiinţe ale Sănătăţii din Moldova, 2022, nr. 3 An.1(29), p. 382. ISSN 2345-1467. |
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Revista de Ştiinţe ale Sănătăţii din Moldova | ||||||
Numărul 3 An.1(29) / 2022 / ISSN 2345-1467 | ||||||
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Pag. 382-382 | ||||||
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Background. Perinatal asphyxia remains a significant cause of perinatal morbidity and mortality, neurological disabilities in newborns. Therapeutic hypothermia remains the standard approach that neuroprotective therapy in the treatment of hypoxic-ischemic encephalopathy (EPHI) in newborns with EPHI. Objective of the study. The goal is to analyze biochemical markers as possible predictors of death in newborns induced or non-induced in hypothermia following perinatal asphyxia. Material and Methods. Patient data were taken from the medical databases: gestation term, birth weight, Apgar score and Sarnat score, gas analysis, lactate before and during the first 12 hours after induction in therapeutic hypothermia. The criteria for inclusion were Sarnat score 2 or 3. Included were 85 newborns after perinatal asphyxia. Results. The characteristics of the patients compared between two groups, induced in therapeutic and non-induced hypothermia. Statistical difference was not found between the groups in terms of gender, gestational age, birth weight, type of birth, Apgar score in the 1st and 5th minute. The groups were significantly different in terms of acid-base balance (p = 0.013), excess base (BE) (p = 0.023), lactate (p = 0.005). Therapeutic hypothermia reduced the risk of death in newborns with moderate to severe EPHI. Conclusion. This study showed that blood gases, lactate, Sarnat score are significant in the group of newborns with hypothermia after suffering perinatal asphyxia. These biochemical markers can serve as prognostic predictors in neurological consequences due to perinatal asphyxia. |
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Cuvinte-cheie hypoxic-ischemic encephalopathy, newborn, therapeutic hypothermia, encefalopatie hipoxico-ischemică, nou-născut, hipotermie terapeutică |
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