Conţinutul numărului revistei |
Articolul precedent |
Articolul urmator |
213 0 |
Căutarea după subiecte similare conform CZU |
616.831-005.1 (93) |
Neurologie. Neuropatologie. Sistem nervos (971) |
SM ISO690:2012 GAVRILIUC, Pavel, LEKER, Ronen, GROPPA, Stanislav. Involvement of the cerebellum in cerebral amyloid angiopathy. In: Revista de Ştiinţe ale Sănătăţii din Moldova, 2022, nr. 3 An.1(29), p. 258. ISSN 2345-1467. |
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Revista de Ştiinţe ale Sănătăţii din Moldova | ||||||
Numărul 3 An.1(29) / 2022 / ISSN 2345-1467 | ||||||
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CZU: 616.831-005.1 | ||||||
Pag. 258-258 | ||||||
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Introduction. Cerebral amyloid angiopathy (CAA) is characterized by deposits of beta amyloid in small and mediumsized vessels of the brain and leptomeninges. Lobar hemorrhage is a primary clinical sign of CAA. A subset of hemorrhages located in the cerebellum are thought to be associated with amyloid storage. Aim of the study. Analysis of the involvement of the cerebellum in CAA. Materials and methods. Patients with spontaneous intracerebral hemorrhage that were investigated by magnetic resonance imaging were selected. Data was accrued retrospectively from 20092015 and prospectively from 2015 to 2019. Patients were diagnosed with CAA according to Boston criteria. The pattern of distribution of microhemorrhages, changes in white matter and cognitive abilities of patients with and without cerebellar involvement were analyzed. Results. Out of a total of 718 patients, 189 (26.3%) were examined by brain MRI. Of the 189 patients, 155 met the Boston criteria for the diagnosis of cerebral amyloid angiopathy. Patients with CAA and cerebellar involvement were younger (67 + -6 years vs 72 + -10 years, p < 0.001), and have more microhemorrhages 33 + -23 vs 3 + -9, p < 0.001. Patients with cerebellar involvement had a more white matter hyperintensities according to the Fazekas scale. In addition, cognitive disorders are more prevalent in patients with cerebellar involvement, 26% versus 3.6%, p < 0.001. Conclusion: cerebellar involvement is not uncommon in CAA. Most patients have cerebellar microbleedings, have a more aggressive microvascular pattern, and more prominent cognitive changes. |
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Cuvinte-cheie stroke, cerebellum, Hemorrhage, amyloid, accident vascular cerebral, cerebel, hemoragie, amiloid |
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