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577.112:616.441-008.64-036 (1) |
Bazele materiale ale vieții. Biochimie. Biologie moleculară. Biofizică (664) |
Patologia sistemului limfatic, a organelor hemopoietice şi endocrine (189) |
SM ISO690:2012 VUDU, Stela, ZOTA, Larisa, RIZOV, Cristina, VUDU, Lorina. Comparison of high sensitivity C-reactive protein level in autoimmune hypothyroidism before and after treatment with levothyroxine. In: Revista de Ştiinţe ale Sănătăţii din Moldova, 2022, nr. 3 An.1(29), p. 251. ISSN 2345-1467. |
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Revista de Ştiinţe ale Sănătăţii din Moldova | ||||||
Numărul 3 An.1(29) / 2022 / ISSN 2345-1467 | ||||||
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CZU: 577.112:616.441-008.64-036 | ||||||
Pag. 251-251 | ||||||
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Background. Hypothyroidism is an undeniable medical problem because it is one of most widespread endocrine diseases. Inflammation is an important part of innate immunity. There are several correlations between autoimmune hypothyroidism and subclinical inflammation, with contradictory results regarding changes in inflammatory biomarkers during treatment. Aim of the study. To evaluate the level of high-sensitivity C-reactive protein (hsCRP) before and after levothyroxine therapy in patients with autoimmune hypothyroidism. Material and Methods. The study included 51 patients with recently diagnosed hypothyroidism, who did not receive hormone replacement therapy. 30 patients were investigated after 2 and 4 months of treatment with levothyroxine with an average dose of 0.7-1.6 mcg/kg/ day. The investigated parameters were TSH) freeT4 (fT4), hsCRP. Results. Out of 51 patients with elevated TSH, 26 had low fT4 (overt hypothyroidism) and 25 had normal fT4 (subclinical hypothyroidism). All the patients had increased anti-TPO and/or anti-thyroglobulin antibodies level. There was a significant decrease in TSH over time (p=0.003) (initial level was on average 44.2 μIU/mL and 6.78 μIU/mL at 4 months). There was a significant increase in FT4 (p < 0.005) (initial level was on average 0.5 ng/dL and 1.1 ng/dL at 4 months). A decrease in hsCRP was observed over time (initial level was on average 2.2 mg/L, 1.69 mg/L at 2 months (p = 0.02) and 1.85 mg/L at 4 months, p = 0.07). Conclusion. This study showed a decrease of hsCRP in patients treated with levothyroxine. |
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Cuvinte-cheie autoimmune hypothyroidism, hsCRP, hipotiroidism autoimun, hsPCR |
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