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242 8 |
Ultima descărcare din IBN: 2023-06-03 17:30 |
Căutarea după subiecte similare conform CZU |
616.27-006.444-07-036.1-08 (1) |
Patologia sistemului respirator. Tulburări ale organelor de respiraţie (757) |
SM ISO690:2012 LOZOVANU, Veronica, TOMACINSCHII, Victor, ROBU, Maria, BURUIANA, Sanda. The results of treatment applied in non-Hodgkin lymphomas with primary mediastinal involvement. In: Revista de Ştiinţe ale Sănătăţii din Moldova, 2022, nr. 3 An.1(29), p. 217. ISSN 2345-1467. |
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Revista de Ştiinţe ale Sănătăţii din Moldova | ||||||
Numărul 3 An.1(29) / 2022 / ISSN 2345-1467 | ||||||
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CZU: 616.27-006.444-07-036.1-08 | ||||||
Pag. 217-217 | ||||||
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Background. Non- Hodgkin’s lymphoma (NHL) is a totality of lymphoproliferative diseases that differ in clinical evolution, morphology, and response to various treatment regimens. The frequency of NHL with primary mediastinal involvement is 2.5- 5.7%. Objective of the study. To study the results of treatment of non- Hodgkin’s lymphomas with primary mediastinal involvement. Material and Methods. They were studied for the treatment of 49 patients aged 20 to 74 years with a diagnosis of mediastinal NHL who were undergoing treatment and evidence in the Hematology Department of the IMSP Oncological Institute of the Republic of Moldova. The evaluation of the response to treatment was determined according to WHO criteria. Results. The treatment was performed with 6-8 cycles of polychemotherapy (PChT) in 31 patients and combined treatment (PChT + radiotherapy) in 18 cases. The PChT regimens used were CHOP in 27 patients and R- CHOP- in 22. When applying the combined treatment, the complete remissions in the local stages constituted 83.3%, in the generalized stages – 66.7%, and after PChT - in 80.0 % and 46.2%, respectively. The percentage of complete remissions was higher when applying PChT R- CHOP, in the local stages- 100%, in the generalized stages- 66.6%. When performing PChT CHOP, complete remissions were obtained in the local stages at 50.0%, in the generalized stages – 35.3% cases. Conclusion. The effectiveness of the treatment was higher when applying the combined treatment and using PChT according to the R- CHOP scheme. The survival of patients over 5 years without progression was 82.6%, and the overall survival was equal to 69.1%. |
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Cuvinte-cheie non-Hodgkin’s lymphoma, mediastinum, treatment, Limfoame non- Hodgkin, mediastin, Tratament |
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