Conţinutul numărului revistei |
Articolul precedent |
Articolul urmator |
198 2 |
Ultima descărcare din IBN: 2023-04-07 19:06 |
Căutarea după subiecte similare conform CZU |
616.24-002-036-092-07-08 (2) |
Patologia sistemului respirator. Tulburări ale organelor de respiraţie (757) |
SM ISO690:2012 CAPRĂ, Dumitru, CALARAŞ, Diana. Clinical and prognostic aspects in hypersensitivity pneumonitis. In: Revista de Ştiinţe ale Sănătăţii din Moldova, 2022, nr. 3 An.1(29), p. 192. ISSN 2345-1467. |
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Revista de Ştiinţe ale Sănătăţii din Moldova | ||||||
Numărul 3 An.1(29) / 2022 / ISSN 2345-1467 | ||||||
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CZU: 616.24-002-036-092-07-08 | ||||||
Pag. 192-192 | ||||||
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Introduction. Hypersensitivity pneumonitis (HP) is an interstitial lung disease that occurs upon sensitization to an inhaled organic antigen. Previously classified as acute, subacute, and chronic, this classification has not been shown to be a good prognostic tool. Lately, the classification of fibrotic (FHP) and non-fibrotic (NFHP) is recommended. Aim of study. Study of differences in patients with FHP and NFHP. Materials and methods. In a retrospective cohort study were analyzed 39 patients diagnosed with HP in IFP Chiril Draganiuc during 2017-2021, based on: exposure to Ag, imaging data, bronchoalveolar lavage (LBA), functional respiratory tests. Results. Mean age of study group was 47±15 years, with 8 (20.5%) patients with NFHP and 31 (79.5%) patients with FHP. The NFHP group is dominated by young patients (35±6.1 years) and women (100%), compared to the FHP group, with mean age 51±11.3 years, with 73% women, p < 0.05. Identification of an Ag in the NFHP group was possible in 69.2%, compared to 35.9% in FHP, p < 0.05. LBA analysis showed alveolar lymphocytosis with values > 40% in 94% of cases, and only 32% in FHP. Functional tests did not reveal statistical differences in FVC, FEV1, TLC, RV or DLCO, but NFHP patients had a 100% improvement of lung function, compared to FHP patients who achieved normal FVC, FEV1, RV and TLC in 15.3 % cases, DLCO remained low in 87.2%, p < 0.05. Conclusions. NFPH was found mainly in females, of young age, where the antigen was frequently identified, and had a favorable prognosis with timely treatment, compared to patients with FPH, where the antigen can rarely be found, and who remain with functional sequelae. |
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Cuvinte-cheie hypersensitivity pneumonitis, fibrosis, pneumonita prin hipersensibilitate, fibroză |
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