Introduction. Traumatic brain injury (TBI) is a major cause of death and disability worldwide. The causes of traumatic brain injury vary by age and other demographic characteristics. Mortality after trauma is higher for elderly than younger patients. Material and methods. This study has been conducted over 468 patients with TBI, which were evaluated by the National Center of Prehospital Emergency Medicine from Chisinau. The retrospectively collected database includes information on age, sex, mechanism of injury, initial Glasgow Coma Scale score. Results: The age of patients varied from 15 to 84 years. The medium average of investigated patients was 49,5 years. This study included 468 cases with 304 (65%) males and 164 (35%) females. Road traffic crashes are the leading cause of TBI, which consist (47.86%). Accidents at home and aggression also occupies an important place in etilogy of head injury (16.88% and 14.1% respectively). Seasonal distribution analysis of traumatic brain injury shows an increased rate of head injury during winter (per season) - 35.89% with the largest spread in February (per month) - 14.74%. The vast majority of patients showed a higher GCS 8 (63.03%). The remaining patients were in coma (36.96%) with a GCS less than 8, GCS 3 – 4 - 10.89%; GCS 5-6 - 10.47%; GCS 7 – 8 - 15.59%. Conclusion: TBI is common and a major public health problem. TBI predominantly affects young male population. Road traffic crashes are the leading cause of TBI.