Conţinutul numărului revistei |
Articolul precedent |
Articolul urmator |
212 0 |
Căutarea după subiecte similare conform CZU |
616.613-003.7-036-089.87 (1) |
Patologia sistemului urogenital. Boli urinare şi sexuale (genitale) (392) |
SM ISO690:2012 ROTARU, Liliana. Coraliform nephrolithises and inflammation. In: Revista de Ştiinţe ale Sănătăţii din Moldova, 2022, nr. 3 An.1(29), p. 54. ISSN 2345-1467. |
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Revista de Ştiinţe ale Sănătăţii din Moldova | ||||||
Numărul 3 An.1(29) / 2022 / ISSN 2345-1467 | ||||||
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CZU: 616.613-003.7-036-089.87 | ||||||
Pag. 54-54 | ||||||
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Background. Acute and chronic inflammatory processes are common in patients with coralliform nephrolithiasis. This is due to many underlying factors, including the uremic environment, oxidative stress (OS), and the increased incidence of infections. OS that occurs when there is an excessive production of free radicals or a low level of antioxidants, induces an increased production of cytokines that instigates inflammatory processes. Objective of the study. To evaluate proinflammatory and anti-inflammatory cytokines in patients with coral nephrolithiasis. Materials and methods. The study was performed on 81 patients with coral nephrolithiasis. Serum levels of cytokines IL-1β, IL-6, TNF-α and Il-10 were evaluated. The data were compared with those obtained in 40 healthy subjects (control group). Results. Levels of Il-1β, Il-6, TNF-α and IL-10 were increased in patients with coral nephrolithiasis above the reference values obtained in the control group. Thus, IL-1β values increased above 49.1 pg/ml (reference values ≤ 5 pg/ml), IL-6 values increased above 145 pg/ml (reference values ≤ 9.7 pg/ml), levels of TNF-α exceeded 30.4 pg/ml (reference values ≤ 8.1 pg/ml), and Il-10 values exceeded 78 pg/ml (reference values ≤ 9.1 pg/ml). Conclusions. Measurement of IL-1β, IL-6, TNF-α and Il-10 is reasonable in patients with coral nephrolithiasis to assess the severity and extent of inflammation. The importance of the obtained data appeared from the fact that therapy with cytokine antagonists today is a rapidly growing and advancing field in clinical practice, with a great pharmaceutical impact. |
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Cuvinte-cheie coralliform nephrolithiasis, cytokines, oxidative stress, nefrolitiază coraliformă, citokine, stres oxidativ |
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