Conţinutul numărului revistei |
Articolul precedent |
Articolul urmator |
249 0 |
Căutarea după subiecte similare conform CZU |
616.214.8-008.14:578.834 (1) |
Patologia sistemului respirator. Tulburări ale organelor de respiraţie (779) |
Virologie (447) |
SM ISO690:2012 RABEI, Elena. Studying changes in the structure of olfactory cilia in patients infected with COVID-19. In: Revista de Ştiinţe ale Sănătăţii din Moldova, 2022, nr. 3 An.1(29), p. 29. ISSN 2345-1467. |
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Revista de Ştiinţe ale Sănătăţii din Moldova | ||||||
Numărul 3 An.1(29) / 2022 / ISSN 2345-1467 | ||||||
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CZU: 616.214.8-008.14:578.834 | ||||||
Pag. 29-29 | ||||||
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Background. The emergence of the pandemic caused by COVID-19 has been considered a real challenge, recently subjected to global research to identify effective treatments, in this context, anosmia being revealed as a dominant symptom. Objective of the study. Study of changes in the structure of olfactory cilia in patients infected with COVID19 and the mechanism of occurrence of anosmia. Material and Methods. The specialized literature was used, consulting the scientific articles in the field. In this regard, the following methods were used: research analysis and synthesis, which made possible the approach of the current findings, related to the subject. Results. The nasal mucosa, consisting of the respiratory and olfactory regions, holds in its structure the ciliated epithelium. It has been shown that SARS-CoV-2 has infected and multiplied in this epithelium. The virus penetrated into the host cell by the interaction of the spike protein(s) with the specific cellular receptor - the angiotensin-converting enzyme 2. As a result, the infected cells were detected by the mechanism of gradual absorption of cilia into the cytoplasm but retained the origin of the basal corpuscle. Anosmia was claimed as a consequence of the destruction of the olfactory ciliated epithelium. It was demonstrated that during the recovery period of the sick person, the cilia regenerated. Conclusion. We conclude that the approach of the current research regarding the structural changes of the cilia in the infection with SARS-CoV-2, has remained an open field to the new investigations. |
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Cuvinte-cheie Cilia, SARS-CoV-2, anosmia, Cili, SARS-CoV-2, anosmie |
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