Introduction: The antibiotic resistance, currently, is one of the most pressing health care problems. On April 7, 2011 WHO held The World Health Day, spent under the title “Antibiotic resistance: No action today – no cure tomorrow.” As prevention and control measures in Europe, The European Antimicrobial Resistance Surveillance System (EARSS) is running, which investigates and takes out the level of resistant strains of dangerous pathogens. Aim: In our study, we conducted a research by the EARSS model for 2 pathogens most often involved in respiratory infections in Moldova: Streptococcus pneumoniae and Streptococcus pyogenes. Methods: The researches have been performed at the National Centre for Public Health, Epidemiology Centre for extremely dangerous diseases, Respiratory diseases department. The results of approximately 400 antibiograms, for the 2009-2010 years, were processed. Results: The incidence of pneumococcal and group A β-hemolytic streptococci infections was estimated among the population of Moldova. The rate of resistant strains of these pathogens to seven antibiotics most commonly used to treat respiratory infections is the following: Str. pneumoniae: to amoxicillin – 11,82%; to cefuroxime – 21,43%; to ceftriaxone – 4,76%; to ciprofloxacin – 4,35%; to erythromycin – 13,95%; to clarithromycin – 9,52% and to azithromycin – 17,02%. Str. pyogenes: to amoxicillin – 11,49%; to cefuroxime – 5,26%; to ceftriaxone – 2,56%; to ciprofloxacin – 2,22%; to erythromycin – 16,46%; to clarithromycin – 17,95% and to azithromycin – 20,51%. Conclusions: It was updated the level of bacterial resistance for Str. pneumoniae and Str. pyogenes to the antibacterial drugs used in the respiratory infections therapy: amoxicillin, cefuroxime, ceftriaxone, ciprofloxacin, erythromycin, clarithromycin and azithromycin.