This article overlooks the geopolitical issues of Moldova integration model in the EU. Moldova can aspire to entry into the EU after the Cyprus model, so that the secessionist Transnistria region may remain isolated in the territorial aspect, like Russian – Kaliningrad region. The acceptance of Moldova in the European Union can cause discrepancies in the economic investment to the detriment of the space controlled by Russia, with which Russia will not agree. This paper proposes a brief geopolitical analysis of the economic integration phenomenon with particular reference to Moldova, Ukraine and Georgia in relation to the expansionist policy of the Russian Federation towards these countries.