The situation with vulnerable people attracted considerable attention of the government and society in Ukraine even in pre-war times. Necessary steps taken to improve this situation were destroyed first by the pandemic of COVID-19 and then by the war. The purpose of this study is to determine the current problems of vulnerable socio-demographic groups in Ukraine caused by Russian full-scale military invasion and to define the consequences and possible solutions. In the analysis, we used the requests for help received by the Red Cross phone hot line, the feedback from volunteers and people who needed help forums of volunteers and online publications. The most frequent and essential was request for medicine. A large share of vulnerable populations was at risk of not receiving critical health care and medicine. Many elderly persons suffered from regular bombings and the absence of electricity, water and food. It was a huge challenge to organize the evacuation of elderly people and particularly people with disabilities to relatively safe regions. Ukraine's health and social support systems are facing exceptional challenges and pressure. The support of volunteers became extremely important. The further destiny of all people and predominantly vulnerable socio-demographic groups in Ukraine will largely depend on whether the whole world can unite to resist Russian aggression.