Introduction:Thrombocytopenia (<100x109/l) is one of the most common bleeding disorders resulting in patients admitted to intensive care with sepsis. Materials & Methods: Clinical case presentation. 51-year-old man was addressed in the Department of Emergency Medicine, with shortness of breath, pain in left abdominal region, vomiting, asthenia, chills. Ill six days, fever, pain in the left abdominal region, flatulence. Physical examination: the overall condition worse, apathetic, marbled skin, moist. 38.8 ° C fever,tachypnea-22/min,SpO2 – 90%, fine crepitate riles, murmur reduced,HR – 135/min. BP - 90/50 mm Hg. Anuria - 24 hours. At the admission: platelets 14.0 x 109/l, Fibrinogen 7.1 g/lDiagnosis: Acute Pancreatitis. SIRS. Polyorganic failure. Results: It wasindicatedCVVH. Total duration of CVVH was 34 hours. The total volume of ultrafiltration was 48219 ml. Acid-base balance and biochemical indices was improved after the use of CVVH. Conclusion: After lowering the intoxication, platelets count increased from 14.0 x 109/L to 110 × 109/l and fibrinogen from 7.1 to 4.3 g/l. CVVH proved to be effective, despite the risk of bleeding, decreased endotoxicosis and assuring the patient a chance at life. CVVH is one of the methods that ensure cleaning blood out of cytokine and other factors that determine platelets consumption.