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<creators>
<creator>
<creatorName>Ciuntu, A.O.</creatorName>
<affiliation>Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“, Moldova, Republica</affiliation>
</creator>
<creator>
<creatorName>Revenco, N.E.</creatorName>
<affiliation>Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“, Moldova, Republica</affiliation>
</creator>
<creator>
<creatorName>Bernic, J.V.</creatorName>
<affiliation>Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“, Moldova, Republica</affiliation>
</creator>
</creators>
<titles>
<title xml:lang='en'>Activity of chemotrypsine and leucinaminopeptidase in urine of the patients with glomerulonephritis</title>
</titles>
<publisher>Instrumentul Bibliometric National</publisher>
<publicationYear>2013</publicationYear>
<relatedIdentifier relatedIdentifierType='ISSN' relationType='IsPartOf'>0041-6940</relatedIdentifier>
<subjects>
<subject>glomerulonephritis</subject>
<subject>nephrotic syndrome</subject>
<subject>children</subject>
<subject>proteolytic enzymes</subject>
</subjects>
<dates>
<date dateType='Issued'>2013-09-12</date>
</dates>
<resourceType resourceTypeGeneral='Text'>Journal article</resourceType>
<descriptions>
<description xml:lang='en' descriptionType='Abstract'><p>Introduction: The aim of the presented study was to determine the activity of chemotrypsine (CT) and leucinaminopeptidase (LA) in urine of children with glomerulonephritis (GN). Material and methods: Was carried out investigation of 40 children with acute GN and nephrotic syndrome, period of relapse and remission. The age of children was in range from 3 to 17 years. The control group comprise 15 conventionally healthy children. Results: In initial stage of acute GN with children with steroid-sensitive nephrotic syndrome was mentioned significant increasing activity of CT in urine in 2.2 fold (0.86 &plusmn; 0.16 nM/s mM creatinine, p &lt; 0.01) compared to control group (0.39 &plusmn; 0.06 nM/s mM creatinine). In patients with steroid-resistant nephrotic syndrome acute GN at the initial stage the activity of CT in urine increased only in 1.5 fold (0.57 &plusmn; 0.12 nM/s mM creatinine) compared to control group. In remission was mentioned decreasing of enzymes in urine, excluding patients with acute GN with steroid-resistant nephrotic syndrome, in which the activity of CT in urine increased in 2.6 fold (1.03 &plusmn; 0.09 nM/s mM creatinine, p &lt; 0.05), compared to control group. In children with steroid-resistant nephrotic syndrome, acute GN, in initial stage of the disease, the activity of LA in urine increased in 2.7 fold (p &lt; 0.01) compared to control group (0.68 &plusmn; 0.05 nM/s mM creatinine). In remission was mentioned decreasing of activity of LA in urine (0.57 &plusmn; 0.14 nM/s mM creatinine) compared to control. Conclusions: The investigation of proteolytic enzymes in urine in children with GN is early diagnostic marker of activity, severity as well as outcome of the disease.</p></description>
</descriptions>
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<format>application/pdf</format>
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</resource>