Aim: Assessment of the spread of genus Helichrysum in the world flora and flora of the Republic of Moldova, in particular the active compounds and pharmacological activity of the species, according to the scientific literature. Methodology: Were evaluated the literature and database of Helichrysum species, their chemical composition and pharmacological activity. Results: The genus Helichrysum (Asteraceae) includes 600 species distributed mainly in dry forest areas, in Europe, Asia and North America. In the Republic of Moldova only one species H. arenarium (L.) Moench(popularly known as everlasting), occurs sporadically on the cliffs of the right bank of the Nistru River, in the landscape reserve "Climăuții de jos", in the Steppe Hills steppes, on the limestones of Naslavcea, with a declining population due to collection, being a vulnerable species. Many research works focus on the investigation of constituents such as phenolic compounds, flavonoids, phytosterols present in the flowers of H. arenarii, indicating that the most important group of compounds responsible for pharmacological activity are flavonoids (naringenin-5-O-glucoside or helichrysin A, kaempferol, quercetin, luteolin, apigenin). In the collection of the Scientific Practical Centre in the Field of Medicinal Plants “Nicolae Testemițanu” SUMPh. It has been introduced H. italicum (Roth) G. Don., rich in phenolic compounds and essential oils (α-cadren, α-pinene, geranyl acetate, limonene, nerol) with cholagogue, antimicrobial, anti-inflammatory properties, also used in the cosmetic industry due to the characteristic odour. Conclusions: The species of Helichrysum are well-known for their secondary metabolite content and the study contributes to increasing knowledge about the spread of genus Helichrysum in the world and the Republic of Moldova flora, which can serve for future investigations on the species (H. arenarium and H. italicum).