Impact of Rotavirus Vaccine Introduction and Vaccine Effectiveness in the Republic of Moldova

Gheorghiţa Stela; Bârcâ Ludmila; Donos Ala; Wasley Annemarie M.; Bîrcă Ion; Cojocaru Radu; Melnic Anatolie; Ciobanu Silviu; Moșina Liudmila; Cortese Margaret M.; Parashar Umesh D.; Lopman Benjamin Alan

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2023-09-13 15:58

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GHEORGHIŢA, Stela, BÂRCÂ, Ludmila, DONOS, Ala, WASLEY, Annemarie M., BÎRCĂ, Ion, COJOCARU, Radu, MELNIC, Anatolie, CIOBANU, Silviu, MOȘINA, Liudmila, CORTESE, Margaret M., PARASHAR, Umesh D., LOPMAN, Benjamin Alan. Impact of Rotavirus Vaccine Introduction and Vaccine Effectiveness in the Republic of Moldova. In: Clinical infectious diseases, 2016, nr. S2(62), p. 0. ISSN 1058-4838. DOI: https://doi.org/10.1093/cid/civ1209

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Clinical infectious diseases

Numărul S2(62) / 2016 / ISSN 1058-4838 /ISSNe 1537-6591

Impact of Rotavirus Vaccine Introduction and Vaccine Effectiveness in the Republic of Moldova

DOI:https://doi.org/10.1093/cid/civ1209

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Gheorghiţa Stela¹, Bârcâ Ludmila², Donos Ala³, Wasley Annemarie M.⁴, Bîrcă Ion¹, Cojocaru Radu¹, Melnic Anatolie¹, Ciobanu Silviu⁵, Moșina Liudmila⁵, Cortese Margaret M.⁶, Parashar Umesh D.⁶, Lopman Benjamin Alan⁶

¹ National Center of Public Health,
² Municipal Clinical Children’s Hospital of Infectious Diseases,
³ Spitalul Orăşenesc pentru Copii nr.2,
⁴ World Health Organization, Denmark,
⁵ World Health Organization,
⁶ Center for Disease Control and Prevention, Atlanta

Teze de doctorat:

Raportat: Optimizarea supravegherii și controlul infecției cu rotavirus bazată pe implementarea vaccinării

Disponibil în IBN: 16 august 2022

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Background. The Republic of Moldova was the first low- to middle-income country in the World Health Organization European Region to introduce rotavirus vaccine (July 2012). We aimed to assess the impact of the rotavirus vaccine program and estimate vaccine effectiveness (VE). Methods. Surveillance for rotavirus gastroenteritis was conducted in 2 hospitals in the capital city of Chisinau starting in September 2009. Monthly rotavirus admissions by age were examined before and after introduction of rotavirus vaccination using interrupted time-series analyses. We performed a case-control study of VE by comparing rotavirus case patients with test-negative controls. Results. Coverage with at least 1 dose of vaccine increased from 35% in year 1 to 55% in year 2 for children <1 year of age. The percentage of hospital admissions positive for rotavirus fell from 45% in the prevaccine period to 25% (rate reduction, 36%; 95% confidence interval [CI], 26%-44%) and 14% (rate reduction, 67%; 95% CI, 48%-88%) in the first and second years after vaccine introduction, respectively, among children aged <5 years. Reductions were most pronounced among those aged <1 year. Significant reductions among cohorts too old to be vaccinated suggest indirect benefits. Two-dose VE was 79% (95% CI, 62%-88%) against rotavirus hospitalization and 84% (95% CI, 64%-93%) against moderate to severe rotavirus. Conclusions. These results consistently point to profound direct and herd immunity impacts of the rotavirus vaccine program in young children in the Republic of Moldova. Vaccine coverage was modest in these early years following introduction, so there remains potential for further disease reductions.

Cuvinte-cheie
case-control, Moldova, rotavirus, surveillance, vaccine effectiveness

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