Assessment of vitamin K levels in women with intrahepatic cholestasis of pregnancy

Chemortan Maria I.; Sagaidak Irina V.; Cernetckii O.

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2023-01-30 03:29

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CHEMORTAN, Maria I., SAGAIDAK, Irina V., CERNETCKII, O.. Assessment of vitamin K levels in women with intrahepatic cholestasis of pregnancy. In: BMC Pregnancy and Childbirth, 2022, nr. 1(22), pp. 1-6. ISSN 1471-2393. DOI: https://doi.org/10.1186/s12884-022-04875-w

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BMC Pregnancy and Childbirth

Numărul 1(22) / 2022 / ISSN 1471-2393

Assessment of vitamin K levels in women with intrahepatic cholestasis of pregnancy

DOI:https://doi.org/10.1186/s12884-022-04875-w

Pag. 1-6

Chemortan Maria I., Sagaidak Irina V., Cernetckii O.

”Nicolae Testemițanu” State University of Medicine and Pharmacy

Disponibil în IBN: 14 iulie 2022

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Intrahepatic cholestasis of pregnancy is a disorder characterized by pruritus and elevated liver function tests and bile acids. Poor vitamin absorption and, as a result, hypovitaminosis K can occur as a result of the pathology. Given the known efects of vitamin K, the authors considered that hypovitaminosis K could increase the risk of coagulopathic hemorrhage in pregnant women. The study revealed that 59.2% of women with intrahepatic cholestasis of pregnancy were diagnosed with hypovitaminosis K; however, 98.6% of women had normal coagulogram indices. Thus, coagulogram markers are more likely to indicate vitamin K activity than its actual level.

Cuvinte-cheie
intrahepatic cholestasis of pregnancy, Obstetric cholestasis, ICP, pregnancy

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