The thermal comfort is an expression of the satisfaction feeling in accordance with the weather conditions. A variable environment is a permanent source of stress for the human being. Maintaining the human body in a thermal balance is possible only if the thermoregulatory mechanism does not make significant efforts to create a state of physiological comfort. The present study proposes an assessment of the relative stress index regime specific to the Eastern Romanian Plain, for the period between 2011 and 2020. This type of assessment is useful in adopting strategies for the adaptation and mitigation to the bioclimatic conditions in the vulnerable regions, through personal adjustments to cope with the heat stress, realistic planning of living, recreation and health facilities etc. In general, the detailed assessment of the bioclimatic indices is interesting and useful in studying their spatial and temporal variation. It is also useful to apply a single reference scale in order to expose properly the people to the weather. Along with the presentation of the weather, it is necessary to describe the conditions of the comfort or the physiological risk related to the climate.