The present research is intended to be an attempt to unify seemingly divergent plans into a unitary whole under the generous covering of semiotics that has the merit of combining, structurally and functionally, the substantial-energetic component of existence (significant) with that of the information field (meaning) following at the same time the relationship of significance resulting in what we call referent or the spatio-temporal reality. This reality, constituted on the necessity-noos axis (the knowing pole) is the substance itself, the germinating principle of history, of the concrete that is maintained in this unity only insofar it participates in the substance. Thus, we have the possibility of knowing reality by analyzing the theory of substance, where the substance returns to itself providing feedback having new meanings, which represent a new context for another semiosis.