Engineering moire superlattices by twisting and stacking two layers of Van der Waals materials has proved to be an effective way to promote interaction effects and induce exotic phases of matter. The high-temperature superconductor Bi2Sr2CaCu2O8+x (Bi-2212) represents a prototypical cuprate superconductor, with weakly bonded van der Waals (vdW) layers. Using a novel cryogenic van der Waals pickup technique, we have fabricated Josephson junctions between two exfoliated Bi-2212 crystals with controlled relative twist angles. To preserve the air- and heat-sensitive Bi-2212 surface's integrity, we handled the devices entirely within argon or high-vacuum environment and kept the devices cold throughout the fabrication process. The resulting junctions support a Josephson critical current density of similar magnitude as the bulk c-axis intrinsic junctions and with Tc within a few Kelvin of the bulk value. With no need of a post-stacking anneal step, the interface shows minimal signs of surface degradation or reconstruction. The junctions' critical current evolves as expected for a d-wave superconductor. Our new fabrication methods open the possibility of creating arbitrarily complex, monolayer Bi-2212 heterostructures. I will discuss the most recent experimental results that hint novel superconducting states appeared at the twisted interface of cuprates vdW Josephson junctions.