Conţinutul numărului revistei |
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321 0 |
SM ISO690:2012 BOLDESCU, Veaceslav, BEHNAM, Mira A.M., VASILAKIS, Nikos, KLEIN, Christian D.P.. Broad-spectrum agents for flaviviral infections: Dengue, Zika and beyond. In: Nature Reviews Drug Discovery, 2017, vol. 16, pp. 565-586. ISSN 1474-1776. DOI: https://doi.org/10.1038/nrd.2017.33 |
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Nature Reviews Drug Discovery | ||||||
Volumul 16 / 2017 / ISSN 1474-1776 /ISSNe 1474-1784 | ||||||
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DOI:https://doi.org/10.1038/nrd.2017.33 | ||||||
Pag. 565-586 | ||||||
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Infections with flaviviruses, such as dengue, West Nile virus and the recently re-emerging Zika virus, are an increasing and probably lasting global risk. This Review summarizes and comments on the opportunities for broad-spectrum agents that are active against multiple flaviviruses. Broad-spectrum activity is particularly desirable to prepare for the next flaviviral epidemic, which could emerge from as-yet unknown or neglected viruses. Potential molecular targets for broad-spectrum antiflaviviral compounds include viral proteins, such as the viral protease or polymerase, and host targets that are exploited by these viruses during entry and replication, including α-glucosidase and proteins involved in nucleoside biosynthesis. Numerous compounds with broad-spectrum antiviral activity have already been identified by target-specific or phenotypic assays. For other compounds, broad-spectrum activity can be anticipated because of their mode of action and molecular targets. |
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Cuvinte-cheie animals, antiviral agents, dengue, Drug design, Flavivirus Infections, Humans, molecular targeted therapy, Virus Internalization, Virus Replication, West Nile Fever, Zika Virus Infection |
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