In this paper were presented the results of the study of in vitro meristem regeneration of autochthonous grapevine cultivars of great interest for viticulture. The current study involved the reaction of 11 grapevine genotypes on three culture media with different hormonal combinations based on MS medium. Deviations registered in the regenerative capacity were dependent primordialy on genotype. The evaluation of meristem regenerative rate showed that the effect of genotype was statistically significant for all of the traits ((P≤0,001). For regenerative rate were recorded significant deviations in frame of one and the same genotypes depending on the health status. It is suggested that virus infection represent an important source of variance in regeneration. The analysis of variance revealed the highest effect of genotypes on the regenerative capacity of the grapevine meristems (75,8 %).