Liver transplantation presents the advanced curative method introduced in the treatment of end staged hepatic pathology for kids and adults. Liver transplantation from live donor was introduced as alternative method for increasing the number of donors and decreasing the mortality and waiting time in the list of patients waiting for liver transplantation with the number of advantages: graft viability, histo ompatibility between donor and recipient, selection and corresponding waiting time of the recipient, donor's liver full preoperative imaging evaluation. Liver transplantation from live donor presents the surgical intervention with major risk, which needs the dividing the vascular system and hepatic tissue in the way to insure the demands of the donor as those for recipient. With the acceptation of this type of liver transplantation so the donor as the doctor should accept the risk of mortality for the donor as for the recipient. Case presentation: Patient C, 53 years, 61 kg, blood group A(II)Rh+ with the diagnosis Liver cirrhosis, mix viral etiology (HBV, HCV), stage of virus reactivation C, MELD 22. Hypersplenism gr. II. Donor. Man 25 years, 72 kg, patient’s son, blood group A(II)Rh+, without any pathology in the past. Hepatic volumetry: right lobe 1285 cm3, left lobe 498 cm3 (31%). Liver biopsy-macrovesicular steatosis 4%. Operation : Orthotopic liver transplantation with right hemiliver from live donor. Postoperative hospital stay was 10 days for donor, 30 days for recipient.