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Articolul urmator |
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Ultima descărcare din IBN: 2024-03-22 22:27 |
SM ISO690:2012 GAINA, Arina, CHESOV, Elena. The role of genetic factors involved in the development of speech and language disorders. In: Cercetarea în biomedicină și sănătate: calitate, excelență și performanță, Ed. 1, 20-22 octombrie 2021, Chişinău. Chișinău, Republica Moldova: 2021, p. 492. ISBN 978-9975-82-223-7 (PDF).. |
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Cercetarea în biomedicină și sănătate: calitate, excelență și performanță 2021 | ||||||
Conferința "Cercetarea în biomedicină și sănătate: calitate, excelență și performanță" 1, Chişinău, Moldova, 20-22 octombrie 2021 | ||||||
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Pag. 492-492 | ||||||
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Background. Speech and language disorders are closely related to heredity and affect between 5% and 8% of preschool children. A better understanding of the genetic component and early intervention can greatly increase the quality of life for children and adults with speech and language disorders. Objective of the study. Elucidation of genes and genetic mutations involved in the development of speech and language disorders. Material and Methods. The research involves the analysis and synthesis of literature data from 93 bibliographic sources, scientific articles generated using the database www.disgenet.org/ , the keywords used: "stuttering", "dysarthria", "dyslexia", "dysgraphia". Results. About 702 genes associated with speech disorders have been identified, of which 116 genes have been identified whose mutations can cause 2 or more types of speech disorders. The genes for stuttering, dyslexia, dysarthria and dysgraphia were studied, the common genes in at least 2 of the disorders were divided into 3 groups, so mutations in 7 genes (ABCA7, APP, GRN, PSEN, SORL1, TOMM40, TREM2) are common for both stuttering and dyslexia, mutations in 20 other genes are common for dyslexia and dysarthria, mutations in 37 genes are common for dysarthria and dysgraphia. No common genes have been identified for dyslexia and dysgraphia. Conclusion. Knowledge of the genes involved could reveal the fundamental neurogenetic pathways underlying language formation, and gene mutations could explain the genetic cause of speech disorders and allow early diagnosis for appropriate early intervention. |
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Cuvinte-cheie Genes, mutations, stuttering, dysarthria, dyslexia, dysgraphia, gene, mutaţii, balbism, disartrie, dislexie, disgrafie |
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