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SM ISO690:2012 VATAMAN, Elena, CERNETCKII, O.. Effects of surgical menopause on bone mineral density and osteoporosis. In: Cercetarea în biomedicină și sănătate: calitate, excelență și performanță, Ed. 1, 20-22 octombrie 2021, Chişinău. Chișinău, Republica Moldova: 2021, p. 398. ISBN 978-9975-82-223-7 (PDF).. |
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Cercetarea în biomedicină și sănătate: calitate, excelență și performanță 2021 | ||||||
Conferința "Cercetarea în biomedicină și sănătate: calitate, excelență și performanță" 1, Chişinău, Moldova, 20-22 octombrie 2021 | ||||||
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Pag. 398-398 | ||||||
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Rezumat | ||||||
Background. Surgical menopause is associated with endocrine disorders and alteration in bone metabolism which contributes to the decrease of bone mineral density (BMD), increase the risk of osteoporosis and fractures, significantly affecting the quality of life of these patients. Objective of the study. The aim of the study was to estimate BMD changes and to assess the risk of fracture in women with surgical menopause of reproductive and premenopausal age. Material and Methods. A prospective observational study was performed. The study included 15 women undergoing surgical menopause: 13 of the women with hysterectomy without ovariectomy and 2 of the women with bilateral ovariectomy (mean age 43.6). BMD was measured by the DXA method-dual energy X-ray absorptiometry at the level of the femoral neck. The risk of fracture was assessed using the FRAX algorithm. Results. The results of the study show that 86.7% of enrolled patients had normal BMD and 13.3% - low BMD (estimated as Z ≤ -2.0 score). After one postoperative year, 60% had normal BMD, 33.3% - low BMD and 6.7% - osteopenia. There was a downward trend in BMD declining by 3% per year (with limits ranging from 1.6-4.2% per year). Following the analysis of the predicted fracture risk for 10 years, it was found that 8 patients had an increased risk of fracture, 5 patients - moderate risk and in 2 patients the risk was not reported because they were up to 40 years old. Conclusion. Hysterectomy with or without oophorectomy may be associated with low BMD, increased risk of osteoporosis and fracture. Early diagnosis and individualized treatment can prevent functional decline, complications and maintain quality of life in this group of patients. |
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Cuvinte-cheie Surgical menopause, osteoporosis, Bone mineral density, Menopauza chirurgicală, osteoporoza, densitatea minerală osoasă |
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