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SM ISO690:2012 CAIPAC, Alina, AGACHI, Svetlana, PASCAL, Rodica, COVTUN, Anna, GUTU, Biatricia, ROTARU, Larisa. Exacerbation of nephrotic syndrome in patients diagnosed with SARS-COV-2. In: Cercetarea în biomedicină și sănătate: calitate, excelență și performanță, Ed. 1, 20-22 octombrie 2021, Chişinău. Chișinău, Republica Moldova: 2021, p. 126. ISBN 978-9975-82-223-7 (PDF).. |
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Cercetarea în biomedicină și sănătate: calitate, excelență și performanță 2021 | ||||||
Conferința "Cercetarea în biomedicină și sănătate: calitate, excelență și performanță" 1, Chişinău, Moldova, 20-22 octombrie 2021 | ||||||
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Background. The SARS-CoV-2 pandemic had a negative impact on all parts of the population, and patients with pre-existing glomerulopathy had a high risk of impairment and worsening of the underlying pathology. Objective of the study. Examination of patients with nephrotic syndrome appeared de novo (after suffering from SARS-CoV-2 infection), or aggravated nephrotic syndrome. Material and Methods. The study was performed on a group of 7 patients, hospitalized in the Nephrology department, IMPS SCR "Timofei Moșneaga" who were investigated clinically and paraclinically (laboratory and instrumental, including kidney biopsy), between 30.03.2021-21.05.2021 . Results. The number of primary patients diagnosed with nephrotic syndrome after suffering from SARS-CoV-2 infection was 3 patients (42.85%). The aggravation of glomerular pathology after SARS-CoV-2, was determined by increasing of the 24-hour urinary protein in 1 patient (14.28%), in 3 patients (42.85%) the presence of nephrotic syndrome was not caused and associated with SARS-CoV-2 infection. Renal biopsy was performed in patients with nephrotic syndrome and post-SARS-CoV-2 infection: in 2 patients (50%) the diagnosis of renal amyloidosis was established, and in 2 patients (50%) - segmental focal glomerulosclerosis with progressive evolution, late stage. Conclusion. SARS-CoV-2 infection was associated with exacerbation of nephrotic syndrome in 4 patients (57.14%), with a more severe evolution of disease and an unfavorable prognosis, and with the unclear pathogenetic mechanism of renal involvement. |
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Cuvinte-cheie nephrotic syndrome, SARS-CoV-2, renal biopsy, sindrom nefrotic, SARS-CoV-2, biopsie renală |
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<?xml version='1.0' encoding='utf-8'?> <oai_dc:dc xmlns:dc='http://purl.org/dc/elements/1.1/' xmlns:oai_dc='http://www.openarchives.org/OAI/2.0/oai_dc/' xmlns:xsi='http://www.w3.org/2001/XMLSchema-instance' xsi:schemaLocation='http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd'> <dc:creator>Caipac, A.</dc:creator> <dc:creator>Agachi, S.A.</dc:creator> <dc:creator>Pascal, R.</dc:creator> <dc:creator>Covtun, A.</dc:creator> <dc:creator>Guțu, B.</dc:creator> <dc:creator>Rotaru, L.A.</dc:creator> <dc:date>2021</dc:date> <dc:description xml:lang='en'><p>Background. The SARS-CoV-2 pandemic had a negative impact on all parts of the population, and patients with pre-existing glomerulopathy had a high risk of impairment and worsening of the underlying pathology. Objective of the study. Examination of patients with nephrotic syndrome appeared de novo (after suffering from SARS-CoV-2 infection), or aggravated nephrotic syndrome. Material and Methods. The study was performed on a group of 7 patients, hospitalized in the Nephrology department, IMPS SCR "Timofei Moșneaga" who were investigated clinically and paraclinically (laboratory and instrumental, including kidney biopsy), between 30.03.2021-21.05.2021 . Results. The number of primary patients diagnosed with nephrotic syndrome after suffering from SARS-CoV-2 infection was 3 patients (42.85%). The aggravation of glomerular pathology after SARS-CoV-2, was determined by increasing of the 24-hour urinary protein in 1 patient (14.28%), in 3 patients (42.85%) the presence of nephrotic syndrome was not caused and associated with SARS-CoV-2 infection. Renal biopsy was performed in patients with nephrotic syndrome and post-SARS-CoV-2 infection: in 2 patients (50%) the diagnosis of renal amyloidosis was established, and in 2 patients (50%) - segmental focal glomerulosclerosis with progressive evolution, late stage. Conclusion. SARS-CoV-2 infection was associated with exacerbation of nephrotic syndrome in 4 patients (57.14%), with a more severe evolution of disease and an unfavorable prognosis, and with the unclear pathogenetic mechanism of renal involvement.</p></dc:description> <dc:description xml:lang='ro'><p>Introducere. Pandemia cu SARS-CoV-2 a avut un impact negativ asupra tuturor categoriilor de populație, iar pacienții cu glomerulopatie preexistentă au prezentat un risc deosebit de afectare și agravare a patologiei de bază. Scopul lucrării. Examinarea bolnavilor cu sindromul nefrotic agravat și cel apărut de novo (după suportarea infecției SARS-CoV-2). Material și Metode. Studiul a fost efectuat pe un lot de 7 pacienți, internați în secția de nefrologie, IMPS SCR „Timofei Mosneaga” care au fost investigați clinic și paraclinic (de laborator și instrumental, inclusiv și biopsie renală), în perioada 30.03.2021-21.05.2021. Rezultate. Numărul pacienților primari depistați cu sindromul nefrotic după suportarea infecției SARS-CoV-2 au fost 3 (42,85%). Agravarea patologiei glomerulare după suportarea SARS-CoV-2, a fost determinată prin creșterea proteinei nictimerale la un pacient (14,28%), iar la 3 pacienți (42,85%) – prezența sindromului nefrotic nu a fost cauzată de infecția SARS-CoV-2. La biopsie renală, la 2(50%) pacienți cu sindromul nefrotic post COVID-19 a fost stabilit diagnosticul de amiloidoză renală și la 2 pacienți (50%) – glomeruloscleroză focal segmentară, evoluție progresivă, stadiul tardiv. Concluzii. Infecția SARS-CoV-2 s-a asociat cu accentuarea sindromului nefrotic la 4 pacienți (57,14%), având evoluția bolii mai severă, cu prognostic nefavorabil, cu mecanismul patogenetic al implicării renale neclar</p></dc:description> <dc:source>Cercetarea în biomedicină și sănătate: calitate, excelență și performanță () 126-126</dc:source> <dc:subject>nephrotic syndrome</dc:subject> <dc:subject>SARS-CoV-2</dc:subject> <dc:subject>renal biopsy</dc:subject> <dc:subject>sindrom nefrotic</dc:subject> <dc:subject>SARS-CoV-2</dc:subject> <dc:subject>biopsie renală</dc:subject> <dc:title>Exacerbation of nephrotic syndrome in patients diagnosed with SARS-COV-2</dc:title> <dc:type>info:eu-repo/semantics/article</dc:type> </oai_dc:dc>