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SM ISO690:2012 BÎSTRIȚCHI, Victoria, CHESOV, Elena. Genetic aspects and risk factors in psoriasis . In: Cercetarea în biomedicină și sănătate: calitate, excelență și performanță, Ed. 1, 20-22 octombrie 2021, Chişinău. Chișinău, Republica Moldova: 2021, p. 19. ISBN 978-9975-82-223-7 (PDF).. |
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Cercetarea în biomedicină și sănătate: calitate, excelență și performanță 2021 | ||||||
Conferința "Cercetarea în biomedicină și sănătate: calitate, excelență și performanță" 1, Chişinău, Moldova, 20-22 octombrie 2021 | ||||||
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Background. Psoriasis is an autoimmune disease, of multifactorial etiology and incidence of 1-3% in the entire population of the globe. The genetic factor plays a key role in the manifestation of psoriasis, including altered expression of more than 1,300 genes in psoriasis lesions. Objective of the study. To study the genetic aspects and risk factors with a major role in the appearance of psoriasis. Material and Methods. Anonymous survey of 564 people diagnosed with psoriasis, of which 440 women and 117 men. There were analized questions from 3 research areas: epidemiological, genetic and clinical. Results. 47.2% of people with psoriasis reported that in their family there are still members affected by the same disease, of which the highest rate refers to the first degree of kinship father and / or mother- 45.56%, followed by second degree kinship brothers-20%, grandmother-19.63%, and other relatives 14.81%. The most affected areas of the body, reported by respondents were: scalp-20.9%, elbow region-16.6%, lower limbs-14.2%, knees-11.6%, upper limbs-10.3%. The first skin manifestations were observed by respondents between 10-24 years. Among the major triggers of the disease were reported stress-44.1%, diet-15.6%, season-14%, smoking-7.3%, etc. Conclusion. The familial character of the disease is expressed in half of the analysed cases with the involvement of relatives of different degrees, both vertically and horizontally. The results of the analysis confirm the role of the genetic and environmental factors in the appearance of psoriasis. |
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Cuvinte-cheie psoriasis, Genes, risk factors, psoriazis, gene, factori de risc |
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