Background and aims: Migraine and syncope can occur in the same patient. Both conditions are known to present an impairment of autonomic regulation. Aim: to evaluate cardiovascular reflexes in syncopal migraine patients and compare with healthy controls. Methods: The study sample consists of 92 persons divided in four groups: Gr I (n=51)-syncopal migraine, Gr. II (n=14)-migraine without syncope, Gr III (n=15)-syncope without migraine and Gr. IV (n=12)-healthy controls. Was performed autonomic cardiovascular tests (Valsalva maneuver, orthostatic testing, deep breathing and isometric exercise). The result was classified as: normal, slight, prominent and severe modification. Results: Abnormal cardiovascular autonomic reflexes presented 88.23% in Gr.I, 92.8% in Gr.II, 100% in Gr.III and 16.7% in Gr.IV (I vs III<0.05, t=2.6; I vs IV< 0.001, t=5.9; II vs IV< 0.001, t=12.9). Slight modification-13.7% in Gr.I, 7.1% in Gr.II, 13.3% in Gr.III and 16.7% in Gr.IV. Prominent modification: 43.1%–Gr.I, 50%–Gr.II, 60%– Gr.III and 0% in Gr.IV (I vs IV<0.001, t=6.2; II vs IV<0.01, t=3.9; III vs IV< 0.001, t=4.5). Severe modification: 31.4%–Gr. I, 35.7%–Gr. II, 26.7%–Gr.III and 0% in Gr.IV (I vs IV< 0.001, t=4.83). Conclusion: All groups present modification of the cardiovascular autonomic reflexes more expressed than in the healthy controls, but syncopal migraine group was severely affected, which could reflect the impairment of the autonomic regulation. Disclosure: Nothing to disclose