Background and Aims: The relation between stroke and COVID 19 infections is largely discussed. During the pandemic, an institutional cohort of patients with COVID 19 infection and neurological manifestation was established. The aim of the study was to evaluate the stroke occurrence in the Moldovan cohort of patients with neurological manifestation and COVID 19 infection. Methods: The retrospective and prospective study of the medical records of patients admitted to the tertiary neurology center from march 2020 till may 2021 was done. We record demographic data, comorbidities, complications, neurologic symptoms in confirmed COVID-19 patients during the consultation or hospital stay. The patients were evaluated at 6 and 12 months by phone. Results: Moldovan cohort of patients with COVID 19 and neurologic manifestation consist of 168 patients (50,6% men and 49,4% women). Had comorbidities 86,9% as presented: arterial hypertension – 83,3%, diabetes mellitus – 23,2%, cardiovascular – 27,4%, obesity – 21,4%. History of neurological disease: dementia 3,0%, Parkinson’s disease 1,2%, stroke – 19,0%, multiple sclerosis – 1,2%, neuromuscular disorder – 1,2%. Complications requiring medical intervention were: dyspnea 44,6%, pneumonia 61,9%, cardiovascular 7,1%, renal insufficiency 1,2%, coagulation disorder 4,2% and mechanical ventilation 16,1%. New neurological findings in patients with COVID-19 infection were: headache (24.4%), vertigo (14,3%), cognitive impairment (35.7%), stupor/coma (22.1%), stroke (62.5%), ataxia (11.4%), spinal cord disorder (7,2%), peripheral neuropathy (5.4%). Mortality rate in the cohort was 22.61%. Conclusions: The Moldovan cohort of patients with neurologic manifestation during COVID 19 infections presented most frequently at the emergency department with stroke, cognitive impairment, and headache.