The aim of the project Innovative Solutions for the Protection and Preservation of Book and Manuscript Paper (ASPIRATION) is to provide solutions through a new preservation process in hitherto unresolved directions. The preservation of historical objects on cellulosic and protein media aims to combine the best available concepts today with knowledge about the reactions of organic solvents and nanotechnology and finally a protective process for storing the artifact in a modified atmosphere with low oxygen concentration. The initial stage consisted in selecting a number of 10 samples of covers belonging to books from the collections of “Moldova” National Museum Complex of Iaşi, with various components such as paper, leather, textiles, adhesives, which were restored-preserved in Research and Conservation-Restoration Center of Cultural Heritage. This was followed by the preparation of an individual file for each object. After evaluating the results, it can be seen in the case of skin samples that the collagen material is in the optimal range of chemical stability. In the case of cellulosic materials, their acidic character is noted with one exception, a value of 7.9. These 19th century materials are composed of cellulose, hemicellulose, lignin and other wood materials, plus dyes, additives, gluing agents and fillers. Through various oxidation, photooxidation or acid hydrolysis reactions, these materials can cause paper bleaching, yellowing or browning and can weaken and weaken the paper, with a significant increase in acidity. Watering capacity shows the degree of vulnerability to hydrolysis reactions.