Introducere. Implementarea unor abordări terapeutice complexe la pacienții vârstnici cu angor pectoral stabil este o problemă importantă în managementul terapeutic şi are ca scop ameliorarea prognosticului şi a calităţii vieţii bolnavilor. Scopul lucrării. Estimarea eficacităţii clinice, paraclinice, evaluarea probei de cicloergometrie şi toleranţei tratamentului complex cu ozon la bolnavii vârstnici cu angor pectoral stabil. Material şi metode. S-a efectuat un studiu la 48 pacienţi cu angor pectoral stabil, cu vârsta cuprinsă între 65-72 ani (în mediu 66,6±4,4 ani), pe parcursul a 3 ani, care au primit perfuzii intravenoase cu ser fiziologic ozonat de 200 ml, cu concentraţia ozonului de 2,5 mg/litru, cu interval de o zi. Toţi bolnavii au fost randomizaţi în 2 loturi: lotul I (de bază; n=26), cărora, concomitent cu tratamentul de bază, li s-a administrat ozonoterapie; lotul II (martor: n=22), cărora li s-a administrat doar tratamentul de bază. Rezultate. La cei pacienți, care au primit tratament combinat cu ozon adiţional la tratamentul de bază, s-a estimat diminuarea numărului de episoade anginoase pe săptămână cu 87,3%, de la 9,1±0,5 până la 0,25±0,03 min, micşorarea consumului de nitraţi – la 0-1 comprimate/zi, frecvenţa palpitaţiilor a diminuat de la 2,6±0,19 până la 1,9±0,16. Concluzii. La administrarea tratamentului complex cu ozon s-a majorat toleranţa pacienţilor vârstnici la efort fizic, s-a înregistrat ameliorarea indicilor hemodinamici, micşorarea frecvenţei acceselor anginoase şi ca o consecinţă – micşorarea numărului de comprimate de nitroglicerină administrate.

Introduction. Implementation of complex therapeutic approaches in elderly patients with stable angina pectoris is represents an important issue in the therapeutic management and due to improve the prognosis and life quality of patients. Objective of the study. Estimation of clinical and laboratory efficacy, and tolerance of complex treatment with ozone therapy in stable angina pectoris by assessing sample cicloergometry in elderly patients. Material and methods. Was performed a study of 48 patients with stabile angina pectoris, aged 65-72 years (average 66.6±4.4 years) over 3 years, which received intravenous infusions administration of the ozonated saline solution of 200 ml, with concentration of ozone 2.5 mg/liter, with an interval of one day. All patients were randomized into 2 groups: the 1st group (basic: n=26), which concomitant with basic therapy, was administered ozone therapy. The II-nd group (control: n=22) administered only the basic treatment. Results. In elderly patients with stable angina pectoris, who received the ozone treatment in combination with additional basic treatment, was determined the reducing episodes number of angina per week to 87.3%, from 9.1±0.5 to 0.25±0.03 min (p<0.001) reduced consumption of nitrates 0-1 tablets / day, palpitations frequency decreased from 2.6±0.19 to 1.9±0.16. Conclusions. After the complex treatment with ozone in elderly patients increased the tolerance to exercises, the hemodynamic improved, decreasing the frequency of the anginal attacks and as a consequence – reducing the administered of nitroglycerin tablets number.