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 SM ISO690:2012MUTHURAMAN, Muthuraman, CIOLAC, Dumitru, CHIRUMAMILLA, Venkata Chaitanya. Translation of functional domain abnormalities from human to mouse motor system. In: Neuromethods, 1 iunie 2021, Berlin. Berlin, Germania: Humana Press Inc., 2021, Vol. 166, pp. 139-152. ISSN 08932336. DOI: https://doi.org/10.1007/978-1-0716-1213-2_10 |
| EXPORT metadate: Google Scholar Crossref CERIF DataCite Dublin Core |
 Neuromethods Vol. 166, 2021 |
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Sesiunea "Neuromethods" Berlin, Germania, 1 iunie 2021 | ||||||
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| DOI:https://doi.org/10.1007/978-1-0716-1213-2_10 | ||||||
| Pag. 139-152 | ||||||
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Multiple sclerosis (MS) is characterized by frequent impairment of motor skills, with the most prominent manifestations being spasticity, gait impairment, fatigue, or disabling tremor, all highly important determinants of physical disability. The optimization of the reverse translation from humans to mice of relevant readouts of abnormal motor function could definitively improve actual models of neuroinflammation to better match human functional outcomes in MS patients. The aim of this chapter is to provide a descriptive methodological framework to approach human motor function abnormalities that could ground a translational pathway from patients to mice. |
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| Cuvinte-cheie EEG, EMG, Evoked potentials fMRI, Human–mice translation, MEG, Motor system |
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