Conţinutul numărului revistei |
Articolul precedent |
Articolul urmator |
325 0 |
SM ISO690:2012 GAVRILIUC, Olga, PASCHEN, Steffen, ANDRUȘCA, Alexandru, SCHLENSTEDT, Christian, DEUSCHL, Gunther D.. Prediction of the effect of deep brain stimulation on gait freezing of Parkinson's disease. In: Parkinsonism and Related Disorders, 2021, nr. 87, pp. 82-86. ISSN 1353-8020. DOI: https://doi.org/10.1016/j.parkreldis.2021.04.006 |
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Parkinsonism and Related Disorders | |||||||
Numărul 87 / 2021 / ISSN 1353-8020 /ISSNe 1873-5126 | |||||||
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DOI:https://doi.org/10.1016/j.parkreldis.2021.04.006 | |||||||
Pag. 82-86 | |||||||
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Objective: The response of freezing of gait (FOG) to deep brain stimulation of the subthalamic nucleus (STN-DBS) is controversial and depends on many poorly controlled factors. On the other hand, a clinical predictor for the individual patient is needed to counsel the patient regarding this symptom. Methods: A cohort of 124 patients undergoing STN-DBS was evaluated based on the video-documented Levodopa test at baseline in the OFF- and ON-drug condition and postoperatively in the best condition (ON-drug/ON-stim) and the worst condition (OFF-drug/ON-stim). We compared the freezing item of the Unified Parkinson's disease rating scale (#14), the UPDRS III total score, and FOG severity rated during four provoking situations with regard to its predictive value. Results: We found ‘FOG during the turning task’ to be the best predictor with an ROC-value of 0.857 compared to 0.603 for the UPDRS Item 14 and 0.583 for the total UPDRS III. An improvement of 1 or 2 grades of the turning item during the preoperative levodopa test predicts an improvement during the worst condition postoperatively of 1 grade or more with an 80% probability. Conclusion: This FOG prediction test is simple and clinically useful. The test needs to be studied in a prospective study. |
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Cuvinte-cheie Deep brain stimulation, Freezing of gait, Parkinson's disease, prediction |
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