New hybrid quaternary salts with pyridine/benzimidazole skeleton

Ciorteanu Roxana Elena; Diaconu Dumitrela; Antoci Vasilichia; Amăriucăi-Mantu Dorina; Ciobanu Catalina Ionica; Mangalagiu Violeta; Mangalagiu Ionel I.

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520

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2024-04-05 01:42

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547.7/.8:577.1+615.011 (1)

Chimie organică (484)

Bazele materiale ale vieții. Biochimie. Biologie moleculară. Biofizică (664)

Farmacologie. Terapeutică. Toxicologie (1596)

SM ISO690:2012

CIORTEANU, Roxana Elena, DIACONU, Dumitrela, ANTOCI, Vasilichia, AMĂRIUCĂI-MANTU, Dorina, CIOBANU, Catalina Ionica, MANGALAGIU, Violeta, MANGALAGIU, Ionel I.. New hybrid quaternary salts with pyridine/benzimidazole skeleton. In: New frontiers in natural product chemistry.: A destiny on the altar of research. Dedicated to academician Pavel Vlad, Ed. 6, 21 mai 2021, Chișinău. Chișinău, Republica Moldova: Tipografia "Artpoligraf", 2021, Ediția 6, p. 23. ISBN 978-9975-3336-7-2. DOI: https://doi.org/10.19261/nfnpc.2021.ab16

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New frontiers in natural product chemistry.
Ediția 6, 2021

Conferința " New frontiers in natural product chemistry."
6, Chișinău, Moldova, 21 mai 2021

New hybrid quaternary salts with pyridine/benzimidazole skeleton

DOI:https://doi.org/10.19261/nfnpc.2021.ab16

CZU: 547.7/.8:577.1+615.011

Pag. 23-23

Ciorteanu Roxana Elena¹, Diaconu Dumitrela¹, Antoci Vasilichia¹, Amăriucăi-Mantu Dorina¹, Ciobanu Catalina Ionica², Mangalagiu Violeta², Mangalagiu Ionel I.¹²

¹ Alexandru Ioan Cuza University of Iaşi,
² Institute of Interdisciplinary Research – CERNESIM Centre

Disponibil în IBN: 28 mai 2021

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Pyridine and pyridine-derived skeletons represents an invaluable scaffolds in drug designing, and also an essential functionality for organic chemists [1]. Over the years, the chemistry of hybrid compounds containing imidazole/benzimidazole and pyridine moieties is developing, due to the fact that novel derivatives have important biological properties such as: anticancer, antimicrobial (antibacterial, antifungal, antitubercular), antimalarial, anti-inflammatory, antidepressant, analgesic, antihypertensive etc. [2-4]. Considering the above, our main objective was to synthesize and characterize novel hybrid quaternary salts with pyridine/benzimidazole skeleton adopting a general and straightforward strategy, involving three steps: I) N-acylation of 2-aminopyridine; II) N-alkylation of benzimidazole; II) quaternization reactions with halogenated derivatives with increased reactivity: p-substituted acetophenones. The structures of newly hybrid pyridine/benzimidazole quaternary salts were proved using NMR experiments (1H, 13C, 2D-correlations). The NMR apparatus (Bruker Advance III 500 spectrometer) is equipped with a 5 mm PABBO detection probe, operating at 500.1 MHz for 1H and 125 MHz for 13C.

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