Early diagnosis of acute mesenteric ischemia (AMI) remains very difficult, partly due to the fact that useful markers of early small bowel ischemia have not yet been identified. Predictive value of procalcitonin (PCT) as serologic marker of AMI is under evaluation [1,2]. This study aimed to determine the value of PCT in the early diagnosis of AMI. A prospective study of eleven consecutive patients with clinical suspicion of AMI was performed. Measurement of PCT levels was performed using a B·R·A·H·M·S PCT-Q25 (B·R·A·H·M·S Aktiengesellschaft, Germany). PCT levels were: ≥ 2 ng/mL in 3 cases and ≥ 10 ng/mL in 8 cases. During laparotomy in all patients was detected bowel necrosis as results of arterial (n=8) and venous (n=3) AMI. Our preliminary results suggest that PCT on presentation is very useful for the diagnosis of intestinal necrosis in AMI and could serve as an additional diagnostic tool to improve clinical decision-making. However, it is necessary to accumulate more observations before formulating the final conclusions.