Simultaneously with increasing of surviving term of cancer patients, as a result of clinical oncology success in malignant tumor’s treatment, was established a rising of frequency of cancer of another organs- primary -multiply cancer. So far diverse opinions are present concerning etiology and pathogenesis of primary multiple malignant tumors of hormone dependent organs. That why primary multiple cancer in general and especially of hormone dependent organs present an actual problem and in the same time complicated for clinical and theoretic oncology.