The concept of a matter object being annihilated when meeting its corresponding anti-matter object is taken over for rule labels as objects and anti-rule labels as the corresponding annihilation counterpart in P systems. In the presence of a corresponding anti-rule object, annihilation of a rule object happens before the rule that the rule object represents, can be applied. Applying a rule consumes the corresponding rule object, but may also produce new rule objects as well as anti-rule objects, too. Computational completeness in this setting then can be obtained in a one-membrane P system with non-cooperative rules and rule / anti-rule annihilation rules when using one of the standard maximally parallel derivation modes as well as any of the maximally parallel set derivation modes (i.e., non-extendable (multi)sets of rules, (multi)sets with maximal number of rules, (multi)sets of rules a ecting the maximal number of objects). When using the sequential derivation mode, at least the computational power of partially blind register machines is obtained.