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Ultima descărcare din IBN: 2022-01-02 19:38 |
SM ISO690:2012 GHILEȚCHII, Alexandru, ROTARU, Tudor. Noi abordări în tratamentul leziunilor intraepiteliale de grad sporit ale colului uterin. In: Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, 21-23 octombrie 2020, Chişinău. Chişinău: USMF, 2020, p. 596. |
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Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” 2020 | ||||||
Congresul "Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”" Chişinău, Moldova, 21-23 octombrie 2020 | ||||||
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Pag. 596-596 | ||||||
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Background. In 2018, according to the latest GLOBOKAN data, 527,600 new cases of cervical cancer patients and 265,700 deaths were diagnosed worldwide. The most important risk factor is HPV infection. Treatment of HSIL lesions of the cervix associated with HPV may delay or prevent progression to cervical cancer. Objective of the study. The aim of this study is to evaluate surgical, antiviral and immunomodulatory treatment in patients with HSIL of the cervix. Material and Methods. This is a prospective study of 26 patients with high-grade intraepithelial lesions of cervical malignancy (CIN II, CIN III, CIS) treated surgically, antivirally and immunomodulatory during the years 2017-2020 in IMSP Oncological Institute of the Republic of Moldova. Results. Case reports of patients which have been analysed ranged from 23 to 48 years old. The average age of the examined patients was 33 years. Patients with HSIL were treated surgically with LLETZ (89%) and total hysterectomy (11%). The postoperative histological result was CIN II-33%, CIN III-56% and CIS-11%. Antiviral therapy was administered to 28% of patients, antiviral and immunomodulatory therapy was administered to 88%, and 12% of patients did not receive any treatment. All patients were monitored by liquid-based cytology + HPV genotyping at 6 months, 88.46% were determined NILM with negative HPV, 11.54%- were determined LSIL + HPV positive insignificant load. Conclusion. The treatment of high-grade neoplasms of the cervix is combined surgically, antiviral and immunomodulatory. At follow-up the cytology was NILM and HPV negative in 88.46% of patients, thus decreasing the risk of recurrence of the disease and a subsequent transformation to cervical carcinoma. |
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Cuvinte-cheie Carcinoma in situ, CIN II, CIN III, HPV, LLETZ, carcinom in situ, CIN II, CIN III, HPV, LEETZ |
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