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Articolul urmator |
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Ultima descărcare din IBN: 2024-03-13 20:12 |
SM ISO690:2012 PRICOP, Ana. Rolul moleculelor complexului major de histocompatibilitate în sistemul imun. In: Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, 21-23 octombrie 2020, Chişinău. Chişinău: USMF, 2020, p. 71. |
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Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” 2020 | ||||||
Congresul "Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”" Chişinău, Moldova, 21-23 octombrie 2020 | ||||||
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Pag. 71-71 | ||||||
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Background. The major histocompatibility complex (MCH) is one of the most studied regions of the human genome. MHC is located on the short arm of chromosome 6 and plays an important role in susceptibility to several human diseases, including autoimmune diseases, type I diabetes, transplant rejection. Objective of the study. The present paper is intended to be a review of the role of MCH and HLA in the human immune system, as well as to identify the relationship between MCH and human pathologies, frequently associated with the inheritance of specific HLA alleles. Material and Methods. A synthesis and analysis of data from the literature was performed. Materials from the electronic databases PubMed, e-library, Libgen, Google Scholar, Sciencedirect, as well as other specialized monographs were used. Relevant sources, which describe the role of MCH in the immune system, were searched for with the keywords "major histocompatibility complex", "human diseases". Results. More than 50 diseases associated with MCH are known. Individual HLA alleles dictate the specificity of T lymphocyte interactions and guide antigen-specific immune events.Polymorphism is involved in the pathogenesis when specific HLA genes are associated with the disease. DR4 and DR5 carriers have an increased predisposition to IgE production and the development of allergic reactions.Carriers of alleles B27 and A2 are resistant to influenza infection.Ankylosing spondylitis is also associated with A2. 90% of patients have this antigen, but in the population there are only 9% carriers of B27.The DR4 antigen is associated with RA, DR3-with SLE, DQ3-with insulindependent diabetes. Conclusion. Class II is most commonly involved in the onset and development of MCH-associated diseases. In most cases, carriers of an HLA molecule are more susceptible to a disease, but there are also examples in which a special allele provides protection against disease. |
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Cuvinte-cheie MCH, immune system, pathology, MCH, sistem imun, patologie |
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