Articolul precedent |
Articolul urmator |
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Ultima descărcare din IBN: 2023-05-12 12:51 |
SM ISO690:2012 PRETULA, Ruslan, CAZACU, Eugeniu, MĂRIȚOI, Tatiana. Studiul histologic și imunohistochimic a 2 cazuri de leiomiom al țesuturilor moi profunde. In: Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, 21-23 octombrie 2020, Chişinău. Chişinău: USMF, 2020, p. 23. |
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Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” 2020 | ||||||
Congresul "Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”" Chişinău, Moldova, 21-23 octombrie 2020 | ||||||
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Background. The low incidence of deep soft tissue leiomyoma, the absence of signs and symptoms of onset in most cases are important problems in attempts to detect the disease early. Objective of the study. The aim of our study is to help elucidate aspects related to tumor pathogenesis and immunohistochemical profile underlying the tumor. Material and Methods. The studied material was represented by the operating parts from the Department of Pathology of the SCR Timofei Moșneaga. The methods used were paraffin inclusion technique and immunohistochemical techniques for assessing the origin and exclusion of a malignant process and its confirmation by the following markers Ki67, EMA, PCK, CD34, SMA, Desmin, Vimentina, S100, Melanosome HMB45, ER, PR. Results. The expression of all these markers on smooth muscle cells in both the normal myometrium and leiomyomas suggests their involvement in uterine functions through autocrine / paracrine mechanisms, directly stimulating tumor growth and progression. Conclusion. The evaluation of the tumor immunoprofile, in correlation with the data from the literat |
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Cuvinte-cheie immunohistochemistry, deep soft tissue leiomyoma, imunohistochimie, leiomiom al țesuturilor moi profunde |
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Cerif XML Export
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The low incidence of deep soft tissue leiomyoma, the absence of signs and symptoms of onset in most cases are important problems in attempts to detect the disease early. Objective of the study. The aim of our study is to help elucidate aspects related to tumor pathogenesis and immunohistochemical profile underlying the tumor. Material and Methods. The studied material was represented by the operating parts from the Department of Pathology of the SCR Timofei Moșneaga. The methods used were paraffin inclusion technique and immunohistochemical techniques for assessing the origin and exclusion of a malignant process and its confirmation by the following markers Ki67, EMA, PCK, CD34, SMA, Desmin, Vimentina, S100, Melanosome HMB45, ER, PR. Results. The expression of all these markers on smooth muscle cells in both the normal myometrium and leiomyomas suggests their involvement in uterine functions through autocrine / paracrine mechanisms, directly stimulating tumor growth and progression. Conclusion. The evaluation of the tumor immunoprofile, in correlation with the data from the literat</p></cfAbstr> <cfAbstr cfLangCode='RO' cfTrans='o'><p>Introducere. Incidența scăzută a leiomiomului țesuturilor moi profunde, absența semnelor și simptomelor de debut, în cele mai multe cazuri, constituie probleme importante în încercările de depistare precoce a bolii. Scopul lucrării. Scopul studiului nostru este de a contribui la elucidarea unor aspecte legate de patogenia tumorii și profilul imunohistochimic ce stau la baza tumorii. Material și Metode. Materialul studiat a fost reprezentat de piesele operatorii din secția Anatomie Patologică a SCR „Timofei Moșneaga”. Metodele utilizate au fost: tehnica de includere la parafină, tehnicile imunohistochimice pentru aprecierea originii și excluderea unui proces malign și confirmarea acestuia prin următorii markeri: Ki67, EMA, PCK, CD34, SMA, Desmin, Vimentina, S100, Melanosome HMB45, ER, PR. Rezultate: Expresia tuturor acestor markeri asupra celulelor musculare netede atât din miometrul normal, cât și din leiomioame sugerează implicarea lor în funcțiile uterine prin mecanisme autocrine/paracrine, stimulând direct creșterea și progresia tumorală. Concluzii. 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