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SM ISO690:2012 NISTOR, Alesea. Ultrasonographic examination in the early diagnosis of seropositive and seronegative rheumatoid arthritis. In: Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, 21-23 octombrie 2020, Chişinău. Chişinău: USMF, 2020, p. 245. |
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Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” 2020 | ||||||
Congresul "Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”" Chişinău, Moldova, 21-23 octombrie 2020 | ||||||
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Pag. 245-245 | ||||||
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Background. ACPA and FR are markers that determine the serological type of rheumatoid arthritis (RA): seropositive (spRA) and seronegative (snRA). The sensitivity and specificity of the ACR / EULAR 2010 Criteria is 75%, therefore it is proposed to apply the Ultrasonography (US) in the early diagnosis of snRA. Objective of the study. Determining the importance of the US examination in the early diagnosis of snRA and predictive differences depending on seropositivity. Material and Methods. 102 patients were included, with symptoms lasting up to 2 years. The RC joints, MCP (II-V), PIP, MTP, TC were examined clinically and US. CRP, ESR, RF, ACPA, Ritchie Articular Index, and VASs were evaluated. The presence of synovial proliferation, synovial vascularization (with Power Doppler (PD)), the presence of erosions, tendinitis and tenosynovitis was evaluated by USG. Results. Patients were divided into 2 groups. Group I - 65 (64%) patients with spRA (RF and / or ACPA positive) and group II - 37 (36%) patients with snRA (RF and ACPA negative). The mean age was 66.5 years (33-67) vs. 58.5 years (23-71). The number of painless and swollen joints was insignificant in the II group. The DAS 28 in group I-4.48(3.42-5.65) vs 5.18(4.31-6.18). SIV - 50 vs 70, which was significantly higher in group II. At the US examination - the presence of synovitis was significantly higher in the seronegative group. The PD score ≥ 2 was significantly higher in the seronegative group. The presence of erosions was in a significantly higher number in spRA. Conclusion. It was found that in patients with snRA the inflammatory activity is more eloquent than in those who are seropositive. The results of the ultrasonographic examination found its value in the correctness of pre-establishing the early diagnosis of RA. |
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Cuvinte-cheie seronegative rheumatoid arthritis, ultrasonography, artrită reumatoidă seronegatvă, ultrasonografie |
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